http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015527886-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-998 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-385 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2503-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-115 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0657 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0735 |
| filingDate | 2013-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2015527886-A |
| titleOfInvention | Method for inducing differentiation of pluripotent stem cells into ventricular cardiomyocytes in vitro |
| abstract | A method for inducing pluripotent stem cells to differentiate into ventricular myocytes in vitro, wherein the pluripotent stem cells are in the middle stage of myocardial differentiation, maintained, amplified and cultured in vitro Sometimes, that is, during the period of differentiation from mesoderm cells or myocardial progenitor cells to cardiomyocytes, by adding to the medium a substance that can directly or indirectly activate the Smad1 / 5/8 signaling pathway A method is provided in the present invention that is realized, thereby allowing stem cells to be directed to differentiate into ventricular myocytes. Ventricular myocytes having biological activity and function can be successfully obtained by the method of the present invention, thereby revealing a control mechanism during differentiation of myocardial progenitor cells into ventricular myocytes, and further through differentiation. The resulting human ventricular myocytes can be widely used in the treatment of myocardial infarction by cell transplantation, in cardiac toxicological analysis, and in the development of cardiac related drugs. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017108705-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021033699-A1 |
| priorityDate | 2012-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 311.