| abstract |
The present invention relates to antibody-polypeptide-cytotoxin conjugates and methods for making, packaging and using the conjugates. The polypeptide can be a Kunitz-type protease inhibitor or a derivative thereof that facilitates transport of the conjugate across the blood brain barrier and / or into cancer cells outside the CNS, and the antibody component can be within the CNS or peripheral. Selectively binds to a target in the tumor and directs the cytotoxic agent to the target (eg, a tumor or cancer cell). The conjugate includes a linker between the antibody component and the polypeptide, the number of the polypeptide and the cytotoxic agent conjugated to it, the position at which the entities within the conjugate bind to each other, and the larger configuration of the conjugate Can be further defined. Modified polypeptides (e.g., polypeptides conjugated to cytotoxic agents rather than antibody components), pharmaceutical compositions, kits (e.g., including antibodies not yet conjugated to modified polypeptides), and conjugates The method of making and using is also a feature of the invention. [Selection] Figure 7 |