http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015525793-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2013-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2015525793-A |
| titleOfInvention | Process for the preparation of sitagliptin and intermediate compounds |
| abstract | Provided are methods for preparing sitagliptin or a pharmaceutically acceptable salt thereof, and methods for preparing intermediate compounds useful in the preparation of sitagliptin. In particular, 3-tert-butoxycarbonylamino-4- (2,4,5-trifluorophenyl) butyric acid of formula (II) and 3- (trifluoromethyl) -5,6,7, of formula (III) 8-Tetrahydro- [1,2,4] triazolo “4,3-a] pyrazine or a salt thereof is condensed in the presence of a catalyst to give (R) -tert-butyl-4- of formula (IV). Oxo-4- (3- (trifluoromethyl) -5,6-dihydro- [1,2,4] -triazolo [4,3-a] pyrazin-7 (8H) -yl) -1- (2, There is provided a process comprising the step of obtaining 4,5-trifluorophenyl) butan-2-yl-carbamate or a pharmaceutically acceptable salt thereof, wherein the catalyst is represented by a compound of formula (V). Compound of formula (IV) or pharmaceutically acceptable thereof That salt is deprotected compound of formula (I). |
| priorityDate | 2012-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 159.