| abstract |
【Task】 Part of the present invention is based on the discovery of an isolated nucleic acid molecule encoding a RAC polypeptide variant, or a fragment thereof, wherein the RAC polypeptide variant is a RAC polypeptide variant in a wild type RAC polypeptide. It includes one or more amino acid substitutions that constitutively activate the body and make it carcinogenic. Such nucleic acid molecules, and vectors, isolated RAC polypeptide variants encoded by host cells, methods of producing encoded polypeptides using such isolated nucleic acid molecules, and identifying, evaluating, prognosing cancer, and Also disclosed are methods of using mutant RAC nucleic acids and polypeptides to treat. [Selection] Figure 1 |