| abstract |
The present invention relates to compounds of formula I, their N-oxides, tautomers, prodrugs and their pharmaceutically acceptable salts and their use for the manufacture of a medicament, wherein in formula I the variables R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the claims, and X is C—R 6 or N and Y is C—R 7 or N, wherein R 6 And R 7 are especially hydrogen, halogen, alkoxy, haloalkoxy and the like. The compounds of formula I, their N-oxides, tautomers, prodrugs and pharmaceutically acceptable salts are inhibitors of phosphodiesterase type 10A and thus have medical disorders selected from neurological and psychiatric disorders. Suitable for treating or inhibiting, ameliorating symptoms associated with such disorders, as well as reducing the risk of such disorders. |