| abstract |
The present invention includes compounds useful in preventing, treating or ameliorating sigma related disorders or diseases. The compounds of the invention may modulate cellular protein homeostasis including: protein translation initiation, folding, processing, transport, and degradation (including ubiquitin-selective autophagy). The invention also includes a method of preventing, treating or ameliorating a sigma-related disorder or disease in a subject in need thereof, comprising the step of administering to the subject an effective amount of a sigma-modulating compound. The present invention is a method for preventing, treating, or ameliorating a sigma-related disorder or disease in a subject in need thereof, comprising the step of administering to the subject an effective amount of a sigma-modulating compound, comprising a ubiquitin proteasome system (UPS) Also included is a method that further comprises administering an effective amount of a compound that inhibits the autophagic survival pathway. |