| abstract |
Specific binding members, particularly human antibodies, particularly recombinant antibodies, and fragments thereof are provided that are capable of binding to, recognizing and eliciting responses in neurons in the CNS. These antibodies are useful for diagnosis and treatment of conditions associated with nerve damage, nerve injury, or neurodegeneration and neurodegenerative diseases, and are particularly useful for the treatment or amelioration of stroke or cerebral ischemia. Antibodies of the invention, their variable regions, or CDR domain sequences, and fragments thereof are also combined in therapy with chemotherapeutic agents, immunomodulators, or neuroactive agents, and / or other antibodies or fragments thereof. Can also be used. The antibodies or active fragments thereof can be used alone or in combination with a thrombolytic agent such as TPA for the treatment of stroke or cerebral ischemia. The antibodies are exemplified by antibodies IgM12 and IgM42, the sequences of which are provided herein. |