| abstract |
Disclosed are 4-((substituted phenyl) difluoromethyl) phenoxycarboxylic acid derivatives, methods for their preparation, and uses thereof. In particular, the invention relates to compounds having the structure represented by Formula I and defined in the specification. The compounds of the present invention can be used as PPAR agonists and have a relatively strong action to reduce total cholesterol (TC), triglycerides (TG), and low density lipoprotein cholesterol (LDL-C) in plasma. Show. Accordingly, the compounds of the present invention treat hyperlipidemia or cardiovascular and cerebrovascular diseases such as diabetes, atherosclerosis, stroke and coronary heart disease caused by hyperlipidemia. Can be used in the preparation of drugs and prophylactics. The present invention also relates to novel intermediate compounds for preparing the compounds of formula I and methods for their preparation. [Chemical 1] |