| abstract |
The present invention is directed to antibodies having a binding specificity for PCSK9 and fragments thereof. Another embodiment of the invention relates to the antibodies described herein comprising the sequences of the V H , VL and CDR polypeptides described herein, and the polynucleotides encoding them, and binding fragments thereof. The present invention also contemplates conjugates of anti-PCSK9 antibodies and binding fragments thereof complexed with one or more functional or detectable moieties. The present invention also contemplates methods for producing such anti-PCSK9 antibodies and binding fragments thereof. Embodiments of the invention also relate to the use of anti-PCSK9 antibodies and binding fragments thereof for the diagnosis, evaluation and treatment of diseases and disorders related to PCSK9. [Selection figure] None |