| abstract |
A sodium channel blocker of formula II is provided, wherein the variable structure moiety is defined herein. The present invention also provides various compositions, combinations and treatment methods using these sodium channel blockers of the present invention. It is an object of the present invention to provide compounds that are more potent and / or are absorbed more slowly from mucosal surfaces such as the ocular surface and / or less reversible compared to known compounds. In particular, it is an object of the present invention to provide a therapeutic method that relies on rehydration of moisture to a viscous surface. |