http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015517478-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-605 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-605 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 |
| filingDate | 2013-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2015517478-A |
| titleOfInvention | Double acylated GLP-1 derivative |
| abstract | The present invention is a derivative of GLP-1 peptide, wherein the peptide has a first K residue at positions corresponding to positions 26 and 34 of GLP-1 (7-37) (SEQ ID NO: 1), respectively. A group and a second K residue, and up to 8 amino acid changes compared to GLP-1 (7-37), wherein the derivative is linked to the first and second via a linker, respectively. It includes two extensions attached to the K residue, the extension being Chem. 2: HOOC-C 6 H 4 -O- (CH 2 ) y -CO- * (wherein y is 6 to The linker comprises Chem. 3a: * -NH- (CH 2 ) q -CH [(CH 2 ) w -NR 1 R 2 ] -CO- * , where q is R 1 and R 2 independently represent * -H or * -CH 3 and w is an integer ranging from 0 to 5, or a pharmaceutical thereof, Permissible salts, amides or esters. The invention also relates to its pharmaceutical use, for example in the treatment and / or prevention of all forms of diabetes and related diseases, and the corresponding novel peptides and linker intermediates. The derivatives are strong, stable and extendable and are suitable for oral administration. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015517477-A |
| priorityDate | 2012-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 419.