| abstract |
The present invention relates to a binding molecule that specifically binds to two different epitopes of an antigen expressed in tumor cells, wherein the binding molecule comprises (a) a first of the antigens expressed in tumor cells. A first binding (poly) peptide that is a Fyn SH3-derived polypeptide that specifically binds to an epitope of; and (b) a second that specifically binds to a second epitope of said antigen expressed in tumor cells. Two linked (poly) peptides. The present invention further relates to a nucleic acid molecule encoding the binding molecule of the present invention, a vector comprising said nucleic acid molecule, and a host cell or non-human host transformed with said vector. The invention further relates to methods for producing the binding molecules of the invention, as well as pharmaceutical and diagnostic compositions. The invention further relates to a binding molecule, nucleic acid molecule, vector or host cell of the invention for use in the treatment of tumors. [Selection] Figure 10 |