| abstract |
Provided is a polymer conjugate comprising a C1 inhibitor having at least one substantially non-antigenic polymer covalently linked to the C1 inhibitor via the amino group of the C1 inhibitor. In these polymer conjugates, a substantially non-antigenic polymer is attached to the N-terminus of the C1 inhibitor. Alternatively, a substantially non-antigenic polymer is attached to the N-terminus of the C1 inhibitor, and at least another substantially non-antigenic polymer is attached to the C1 inhibitor lysine and / or histidine. In addition, these polymer conjugates are bound to the C1 inhibitor via either a permanent spacer or a releasable spacer. Furthermore, methods for producing these conjugates as well as therapeutic methods using the conjugates of the present invention are also provided. [Selection figure] None |