| abstract |
The present invention relates to compositions comprising therapeutic antibodies, and uses and methods for increasing the efficacy of therapeutic antibodies. In particular, the present invention provides a composition comprising (i) an agent that reduces Fc receptor binding of an endogenous serum antibody, and (ii) a therapeutic antibody, preferably a therapeutic antibody that is resistant to that agent. The therapeutic antibody can be administered to the subject after a certain time interval, or the subject's blood can be treated with the agent prior to administering the therapeutic antibody. |