http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015509486-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2863 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2866 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-3804 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-3809 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-289 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-3274 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-3204 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-065 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-3208 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-321 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-3212 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-3219 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-1027 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 |
| filingDate | 2013-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2015509486-A |
| titleOfInvention | Ligand for purification of antibodies and Fc fusion proteins by affinity chromatography IV |
| abstract | The present invention relates to the use of a ligand displacement matrix comprising a support material and at least one ligand covalently bound to the support material for affinity purification of an antibody or antibody fragment, wherein the ligand is of formula (I) expressed. [Chemical 1] here, L is the point of attachment of the support material to which the ligand is attached; Sp is a spacer group; v is 0 or 1; Am is an amide group —NR 1 —C (O) —, where NR 1 is attached to Ar 1 and —C (O) — is attached to Ar 2 , or —C (O) — is Ar adhering vital NR 1 to 1 is either or attached to Ar 2; R 1 is hydrogen or C 1 -C 4 alkyl, more preferably hydrogen or methyl, most preferably hydrogen; Ar 1 is a 5-, 6- or 7-membered mononuclear aromatic ring or a partially saturated aromatic ring which is connected to Sp or L via a chemical bond, and optionally, (A) is attached to an additional 5- or 6-membered mononuclear aromatic ring via a chemical bond; or (B) as part of a polynuclear ring system fused to a mononuclear or binuclear aromatic ring; Here, Ar 1 is either directly connected to Am via a chemical bond in the 6- or 7-membered aromatic ring constituting Ar 1, wherein the additional 5 or attached to Ar 1 6 Either indirectly linked to Am via a chemical bond in a membered aromatic ring or a chemical bond in said further 5 or 6 membered aromatic ring fused to Ar 1 ; Ar 1 is not further substituted or is C 1 -C 4 alkyl; C 3 and C 4 cycloalkyl; C 2 -C 4 alkenyl; C 2 -C 4 alkynyl; halogen; C 1 -C 4 haloalkyl; hydroxy-substituted C 1 -C 4 alkyl; C 1 -C 4 alkoxy; hydroxy-substituted C 1 -C 4 alkoxy; halogen-substituted C 1 -C 4 alkoxy; C 1 -C 4 alkylamino; C 1 -C 4 alkylthio; - Or attached to at least one substituent selected from NO 2 ; = O; = S; = NH; —OH; and combinations thereof; Ar 2 is a 5- or 6-membered mononuclear aromatic ring which is unsubstituted or C 1 -C 6 alkyl; C 3 -C 6 cycloalkyl; C 2 -C 6 alkenyl; C 5 and C 6 cyclo alkenyl; C 2 -C 6 alkynyl; a halogen; C 1 -C 6 haloalkyl; hydroxy-substituted C 1 -C 6 alkyl; C 1 -C 6 alkoxy; hydroxy-substituted C 1 -C 6 alkoxy; halogen-substituted C 1 -C 6 alkoxy; C 1 -C 6 alkylamino; C 1 -C 6 alkylthio; carbamoyl; methylenedioxy; ethylenedioxy; —OH; —SH; and a chemical bond to at least one substituent selected from combinations thereof Optionally, Ar 2 is 5 or 6 membered as part of a polynuclear ring system in addition to the substituents it may be attached via chemical bonds as described above. Ring mononuclear aroma Fused with. [Selection figure] None |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11066446-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2018181738-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018181738-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018061509-A1 |
| priorityDate | 2012-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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