| abstract |
The present invention performs skin depigmentation of at least one microRNA selected from hsa-miR-330, hsa-miR-7 and hsa-miR-137, mature forms thereof, and precursors thereof. For use. The present invention is also an in vitro method for identifying a depigmenting compound comprising the steps of: a) contacting at least one test compound with a sample of melanocytes; b) in said melanocytes, miR-330, miR-7. And measuring the expression or activity of at least one microRNA selected from miR-137, its mature form, and its precursor, c) treated in step a) by comparison with intact melanocytes Selecting a compound wherein the activation of at least one expression or activity of said microRNA measured in melanocytes is at least 20%. |