http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015506948-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55577 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1051 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1077 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-08 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-08 |
| filingDate | 2013-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2015506948-A |
| titleOfInvention | Vaccine against Clostridium difficile containing recombinant toxin |
| abstract | The present invention relates to recombinant C. difficile toxin A (TcdA) and toxin B (TcdB) containing mutations specifically defined for the native toxin sequence that substantially reduce or eliminate toxicity. It relates to a binary toxin A (CDTa) protein. The invention also relates to vaccines and immunogenic compositions comprising these recombinant toxins and combinations of these toxins and binary toxin B (CDTb) that can provide protection against Clostridium difficile infection and / or its effects. . The present invention also relates to a method of inducing an immune response against Clostridium difficile comprising administering to a patient a vaccine and an immunogenic composition described herein. The invention also includes methods for expressing recombinant Clostridium difficile toxin A and toxin B and CDTa mutants and CDTb in a recombinant expression system. In an exemplary embodiment, TcdA, TcdB and CDTa mutant toxins containing sufficient mutations to substantially reduce or eliminate toxicity are expressed in a baculovirus / insect cell expression system. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7149285-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020509770-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016504993-A |
| priorityDate | 2012-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 166.