| abstract |
Disclosed herein are major histocompatibility complex (MHC) class II α1 domain polypeptides and methods of use thereof. In some embodiments, the isolated polypeptide comprises or consists of an MHC class II α1 domain polypeptide (or portion thereof) and does not comprise an MHC class II α2, β1, or β2 domain. The disclosed MHC class II α1 domain polypeptides are used in the treatment or inhibition of disorders in a subject, such as, for example, inflammatory and / or autoimmune disorders. Also disclosed are methods for assessing or optimizing the effect of treatment of a subject using an MHC class II α1 domain polypeptide (or a portion thereof) or a polypeptide comprising an MHC class II α1 domain and a β1 domain (eg, β1α1RTL). ing. [Selection figure] None |