| abstract |
The present invention relates to an antibody or fragment thereof that binds to a non-linear epitope within domain 3 of the HER3 receptor and inhibits both ligand-dependent and ligand-independent signaling. The invention also relates to an antibody or fragment thereof that binds to an amino acid residue in domain 3-4 of HER3 and inhibits both ligand-dependent and ligand-independent signaling; and such an antibody or fragment thereof And compositions of use. |