Predicate |
Object |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-351 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-346 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3233 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-314 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-353 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65846 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1131 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65616 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65583 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65586 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-16 |
filingDate |
2012-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate |
2015-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
JP-2015500204-A |
titleOfInvention |
Functionally modified oligonucleotides and subunits thereof |
abstract |
Functionally modified oligonucleotide analogs comprising modified intersubunit linkages and / or modified 3 'and / or 5' end groups are provided. The disclosed compounds are useful in the treatment of diseases, where inhibition of protein expression or modulation of aberrant mRNA splice products results in beneficial therapeutic effects. In one embodiment, a compound comprising a backbone comprising a sequence of morpholino ring structures connected by an intersubunit linkage connecting the 3 ′ end of a morpholino ring structure to the 5 ′ end of an adjacent morpholino ring structure, each Described herein are compounds in which the morpholino ring structure is attached to a base-pairing moiety and the compound can bind to a target nucleic acid in a sequence specific manner. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021095875-A1 |
priorityDate |
2011-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |