abstract |
The present invention provides suitable active pharmaceutical ingredients for pharmaceutical compositions useful in the treatment of diseases characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, such as cancer. A solid crystalline form of ABT-263 represented by the following formula, wherein the crystalline form is a solvate containing ABT-263 free base solvated with an organic solvent, and the solvate comprises: Ethanol / ethyl acetate mixture, 1-propanol, 2-propanol, methanol, benzene, toluene, dioxane / hexane mixture, methyl acetate / hexane mixture, chloroform, ethyl acetate, isopropyl acetate, methyl acetate, pyridine, anisole or trifluorotoluene A compound selected from solvates. [Selection] Figure 1 |