| abstract |
Methods for selecting cells (one or more), tissues (one or more) or cell cultures (one or more) that are sensitive to HSP90 inhibitors, sputum, with HSP90 inhibitors Providing a method for determining the responsiveness of mammalian tumor cells or cancer cells to treatment. A) determining the presence of at least one activating mutation of the KRAS gene in a cell, tissue or cell culture; (b) a cell, tissue having at least one activating mutation of the KRAS gene; Or selecting a cell culture (c) contacting the cell, tissue or cell culture with an HSP90 inhibitor; and (d) viability of the cell, tissue or cell culture contacted with the HSP90 inhibitor. A method for determining the responsiveness of tumor cells or cancer cells to an HPS90 inhibitor comprising the step of evaluating [Selection figure] None |