| abstract |
The present invention provides methods, compounds, and compositions for reducing the expression of Factor 11 mRNA and protein. Antisense compounds for use in individuals in need of reducing factor 11 to treat or prevent thromboembolic complications. A compound having a modified oligonucleotide consisting of 12-30 linked nucleosides targeting a Factor 11 nucleic acid, wherein the nucleic acid sequence of the modified oligonucleotide is at least 90% in an equal length portion of the Factor 11 nucleic acid Said compound being complementary. Antisense compounds targeted to factor 11 are also used as prophylactic and therapeutic agents to prevent individuals at risk for thrombosis and embolism. [Selection figure] None |