| abstract |
The present invention relates to a novel polymer complex of a polypeptide variant of HMGB1 high affinity binding domain Box-A (HMGB1 Box-A) or a biologically active fragment of HMGB1 Box-A. Furthermore, the present invention relates to a novel polymer complex of a polypeptide variant of HMGB1 high affinity binding domain Box-A (HMGB1 Box-A). Furthermore, the present invention provides a polypeptide molecule of Box-A of HMGB1 for diagnosing, preventing, reducing and / or treating a pathological condition associated with extracellular HMGB1 and / or a pathological condition associated with increased expression of RAGE. To the use of said polymer composite. Provided is a polymer conjugate of a human and / or non-human wild type HMGB1 high affinity binding domain Box-A (HMGB1 Box-A) or a biologically active fragment of HMGB1 Box-A. [Selection figure] None |