| abstract |
Disclosed is a compound that inhibits indoleamine 2,3-dioxygenase. Here, the following equation is shown: And a pharmaceutical composition comprising the compound, R 1 , R 4 and R 5 are defined herein. Such compounds and compositions alleviate the activity of indoleamine 2,3-dioxygenase, treat indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression, enzyme activity of indoleamine 2,3-dioxygenase It is useful for the treatment of conditions ameliorated by inhibition of anticancer drugs, enhancing the effects of anticancer drug treatment including administration of anticancer drugs, treating tumor-specific immunosuppression, and treating immunosuppression associated with infectious diseases. [Selection figure] None |