| abstract |
The present invention provides a method of using a compound used in the manufacture of a medicament for treating an insulin resistance disorder in a human in need of treatment. A non-naturally occurring compound for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistant disease such as diabetes in a subject. Treatment includes the step of increasing or decreasing fat accumulation, respectively, by contacting the cells with, for example, a sirtuin activating compound or inhibitory compound represented by formula (1). [Selection figure] None |