| abstract |
A rifaximin [(2S, 16Z, 18E, 20S, 21S, 22R, 23R, 24R, 25S, 26S, 27S, 28E) -5,6, a synthetic rifamycin antibacterial agent with improved solubility and stability , 21,23,25-pentahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7- (epoxypentadeca- [1,11,13] -trienimino ) Provision of benzofuro- [4,5-e] -pyrido- [1,2-a] -benzimidazole-1,15- (2H) -dione, 25-acetate (I)]. A complex comprising rifaximin and a complex-forming agent, wherein the complex-forming agent is polyvinylpyrrolidone (PVP) or cyclodextrin. Methods for producing the complex, pharmaceutical compositions comprising the complex, and therapeutic uses of the complex. [Selection] Figure 1 |