| abstract |
Disclosed are pharmaceutical compositions and methods for treating or preventing microbial infections. The present invention relates to ketolide compounds of formula (I) and their pharmaceutically acceptable salts, solvates, hydrates, polymorphs and stereoisomers having antibacterial activity. The invention also provides a compound of the invention wherein T is —C * H (R 1) —PQ, R 1 is hydrogen, P is a 6-membered heteroaryl ring, and Q is unsubstituted or A pharmaceutical composition containing a substituted aryl or heteroaryl ring, P is linked to Q via a carbon-carbon bond, and R3 is fluorine, and a compound using the compounds of the invention Methods for treating or preventing infections are provided. [Selection figure] None |