abstract |
The present invention relates to an IL-6 antagonist such as an antibody having a binding specificity to IL-6 and a fragment thereof for preventing or treating thrombosis in a disease associated with abnormal blood coagulation or fibrinolysis. Intended for therapeutic methods using. In preferred embodiments, these patients include patients exhibiting elevated D-dimers or other coagulation cascade-related proteins, optionally further exhibiting elevated C-reactive protein prior to treatment. The subject therapy may also include administration of other active agents such as chemotherapeutic agents, anticoagulants, statins. [Selection figure] None |