abstract |
Disclosed are compositions and methods useful for the modulation of signaling through Toll-like receptors TLR7 and / or TLR8. Compositions and methods useful for the modulation of signaling through Toll-like receptors TLR7 and / or TLR8 are provided. These compositions and methods have application in the treatment or prevention of diseases including cancer, autoimmune diseases, infectious diseases, inflammatory disorders, graft rejection, and graft-versus-host disease. The present invention further provides a method of modulating the immune system of a mammal, the method comprising administering to the mammal a compound of the present invention or a salt thereof in an amount effective to modulate the immune system. Is included. [Selection figure] None |