| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8203ef03c499d81e922ada06873c8fd0 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-02 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C215-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-403
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-29
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C215-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-52 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-52 |
| filingDate |
2015-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_217b6167603c76fdb0a3268b7c9c4f35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb5402cddefcfdbfed8ec2cca3ddaae3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_519471d38f55cc75f115fac3d0dee9e3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03969db747883fc3393895dd0e6a6f47 |
| publicationDate |
2015-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2015145398-A |
| titleOfInvention |
Process for the synthesis of (+) and (-)-1- (3,4-dichlorophenyl) -3-azabicyclo [3.1.0] hexane |
| abstract |
The present invention relates to (+) and (-)-1- (3,4-dichlorophenyl) -3-azabicyclo [3.1, useful as an active ingredient of a therapeutic agent for depression, anxiety disorder, eating disorder and urinary incontinence. 0.0] Providing a simple and highly efficient method for producing hexane or a pharmaceutically acceptable salt thereof. (1) A step of reacting 3,4-dichlorophenylacetonitrile and optically active epichlorohydrin to obtain a cyclopropyl compound; (2) An amino alcohol compound is obtained by reducing the cyclopropyl compound with a reducing agent. (3) including a step of chlorinating the amino alcohol compound with a chlorinating agent to obtain a chloro compound; and (4) a step of dehydrating and cyclizing the chloro compound with a base (+) and (−) − 1. -(3,4-dichlorophenyl) -3-azabicyclo [3.1.0] hexane, or the manufacturing method of those pharmaceutically acceptable salts. [Selection figure] None |
| priorityDate |
2006-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |