| abstract |
The present invention provides a fusion protein that forms a trimer that enables efficient production of a recombinant that combines good trimerization properties and improved pharmaceutical properties. The present invention provides (i) a. A collectin family carbohydrate recognition domain; and b. A collectin family trimerization domain comprising a collectin family neck region; (ii) a linker element; and (iii) an effector polypeptide, wherein the effector polypeptide is located at the N-terminus of the collectin family neck region ). As described herein, this fusion protein, the nucleic acid encoding it, is suitable as a pharmaceutical composition or for therapeutic, diagnostic and / or research applications. [Selection figure] None |