| abstract |
Disclosed is a compound that selectively interacts with α7-containing neuronal nAChRs, α4β2nAChRs, or both α7nAChR and α4βnAChR. A 3-substituted-azaadamantane compound of formula I. [L1 is -O- or -NRa-; Ra is H or alkyl; A is Ar1, Ar2-L2-Ar3, etc .; Ar1 and Ar3 are aryl or heteroaryl; Ar2 is aryl or monocyclic heteroaryl; L2 is a bond; O-, -NRR-, -C (O) NRa- or -CH2] As specific compounds, (4s) -4- (6-phenylpyridazin-3-yloxy) -1-azatricyclo [3.3.1. 13,7] decane; 5- [2- (1-azatricyclo [3.3.1.13,7] decan- (4s) -yloxy) thiazol-5-yl] -indoline-2-one and the like are exemplified. The [Selection figure] None |