| abstract |
A novel injectable composition comprising a botulinum toxin that can be administered to a subject for various therapeutic, aesthetic and / or cosmetic purposes. A positively charged carrier comprising a positively charged backbone with a plurality of efficiency groups attached thereto, a botulinum toxin complex, a reduced botulinum toxin complex, or a botulinum toxin, wherein said positively A composition wherein a charged carrier is present in a non-covalent association with the botulinum toxin complex, reduced botulinum toxin complex, or botulinum toxin. Examples of the carrier include polyamino acids such as polylysine and polyarginine. [Effect] The injectable composition has reduced antigenicity, reduced tendency to cause unwanted local diffusion after injection, increased duration of clinical efficacy or increased relative efficacy, more effective clinical efficacy It shows one or more advantages over conventional botulinum formulations, including fast onset and / or improved stability. [Selection figure] None |