abstract |
A homogeneous product having improved pharmacokinetic and therapeutic properties, reduced binding to inhibitory antibodies to related proteins, long duration of action in vivo, and uniform product Providing the product biocompatible polymer-composite functional FVIII polypeptide and pharmaceutical composition thereof. A factor VIII procoagulant activity comprising a functional factor VIII polypeptide covalently linked to one or more biocompatible polymers at one or more predefined sites on the polypeptide. A pharmaceutical composition comprising a complex having and a pharmaceutically acceptable additive. A complex containing polyethylene glycol, wherein the biocompatible polymer comprises methoxy polyethylene glycol. The pharmaceutical composition is used for the treatment of hemophilia A. [Selection figure] None |