| abstract |
An oligonucleotide capable of activating RIG-I in a cell expressing RIG-I and inducing an antiviral response, particularly an IFN response, and activating RIG-I and having a target gene suppressing activity An oligonucleotide is provided. An oligonucleotide having a double-stranded portion of at least 19 bp, preferably at least 21 bp, at least one 5 ′ triphosphate, and at least one blunt end with 5 ′ triphosphate. Use of the oligonucleotides can induce antiviral responses, particularly IFN responses, in vitro and in vivo, and further prevent and / or treat diseases or conditions such as infections, tumors / cancers and immune disorders I can do it. [Selection figure] None |