| abstract |
The present invention provides a novel immunogen comprising an antigenic PCSK9 peptide, preferably linked to an immunogenic carrier, for preventing, treating or alleviating PCSK9-related disorders, allowing control of LDL cholesterol levels. An antigenic proprotein convertase subtilisin-kexin type 9 (PCSK9) peptide consisting of a specific amino acid sequence, and an immunogenic carrier CRM197 (non-toxic but diphtheria toxin has the same antigenicity) Linked to an immunogenic carrier selected from a variant) and a virus-like particle (VLP), or further comprising an amino acid linker, wherein: (i) the amino acid linker is added to the C-terminus of the antigenic PCSK9 peptide And (ii) an immunogen in which the antigenic PCSK9 peptide is linked to an immunogenic carrier through a cysteine residue of an amino acid linker. [Selection figure] None |