| abstract |
An antibody and a functional fragment comprising a recombinant antigen binding region and such antigen binding region specific for CD38, a nucleic acid sequence encoding said antibody, a vector comprising said sequence, a pharmaceutical composition and use Instructions and provision of new isolated epitopes of CD38 and methods of use thereof. An isolated antibody or functional antibody fragment comprising an antigen-binding region specific for an epitope of CD38. When human PBMC cells are used as effector cells, and when the ratio of effector cells to target cells is between about 30: 1 and about 50: 1, than chimeric OKT10 antibodies having certain heavy and light chain sequences Due to antibody-dependent cytotoxicity (“ADCC”) with at least 2 to 5 times better efficiency, the antibody or functional fragment thereof can be expressed in CD38 + target cells (LP-1 (DSMZ: ACC41) and RPMI-8226). A pharmaceutical composition capable of mediating the killing of (ATCC: CCL-155)). [Selection figure] None |