abstract |
The present invention provides IL-17A / F heterodimeric polypeptides and therapeutic uses thereof. The present invention provides a novel naturally occurring interleukin-17 and interleukin-17F heterodimer described herein as interleukin-17A / F (IL-17A / F). Relates to existing human cytokines. A vector and host cell containing these nucleic acid sequences, a chimeric polypeptide molecule comprising a polypeptide of the invention fused to a heterologous polypeptide sequence, a specific antibody that binds to the polypeptide of the invention, and a polypeptide of the invention A method for producing is also provided herein. Further provided herein are methods for treating degenerative cartilage disorders and other inflammatory diseases. [Selection figure] None |