| abstract |
Disclosed is a peptide or peptidomimetic having high conformational rigidity, metabolic stability and cell permeability, and a method for preparing and using the peptide or peptide mimetic. A peptidomimetic macrocycle containing an amino acid represented by formula (I), an amino acid analog, and a macrocycle to which a linker, a fluorescent moiety, a radioisotope, a therapeutic agent, or the like that forms the macrocycle is bound. Compounds, methods for their synthesis and kits useful for their production. (A and C to E are each independently an amino acid; B is an amino acid analog, etc. -NH-L3-CO-, etc .; R 1 and R 2 are each independently H, halogen-substituted / unsubstituted alkyl, arylalkynyl, etc. R 3 is H, alkyl, cycloalkyl, etc.) [Selection figure] None |