| abstract |
The present invention provides a formulation comprising linaclotide. The present invention relates to stable compositions comprising linaclotide, and various methods and processes for the preparation and use of the compositions. In some embodiments, a pharmaceutical composition of linaclotide is provided, wherein the composition comprises a stabilizing amount of a polymer, a stabilizing amount of a sterically hindered primary amine, a stabilizing A quantity of cations, or combinations or mixtures thereof. In some embodiments, a method is provided for treating a gastrointestinal disorder comprising administering to a subject in need of treatment for a gastrointestinal disorder a therapeutically effective amount of the composition. [Selection figure] None |