| abstract |
A controlled release of phenolic opioids is provided. Using prodrugs that can release phenolic opioids upon activation of the enzyme by intramolecular cyclization that results in the formation of cyclic urea, carbamate, or thiocarbamate, patients are treated with phenolic opioids. A method of providing controlled release. Specifically, this method comprises administering to said patient a corresponding compound substituted with a spacer leaving group having a nitrogen nucleophilic group in which the phenolic hydrogen atom is protected with an enzymatically cleavable moiety. including. [Selection figure] None |