| abstract |
PROBLEM TO BE SOLVED: To provide a vaccine that targets professional antigen-presenting cells (PAPC), is safe, cost-effective, easy to use, and elicits a strong and specific cellularity and antibody response. For in vivo vaccination and effective delivery of one or more antigens for antibody (eg, monoclonal antibody) production and for PAPC or MHC class II positive cells (eg, Nanoparticle-based vaccines, compositions, kits, and methods are used for effective delivery of peptides, proteins, siRNA, RNA or DNA to tumor cells. For example, the antigen may be DNA that is linked to the expression of the gene of interest and the induction of a strong and specific immune response to the expressed protein in a subject (eg, a mammal). The antigen may also be an immunogenic peptide or polypeptide that is processed and presented. [Selection] Figure 1 |