| abstract |
A modified luciferase protein that is a sensor for a molecule containing cAMP is provided. The modified luciferase protein includes one or more heterologous amino acid sequences, at least one of which directly or indirectly interacts with cAMP, and includes a cAMP binding site in the modified luciferase and a target molecule such as a cyclic nucleotide. A polynucleotide having an agent that modulates the interaction between them, an agent that regulates the presence or amount of cyclic nucleotides, or an agent that regulates molecules such as receptors associated with intracellular cyclic nucleotide concentration. [Selection] Figure 7A |