| abstract |
A method for producing a modulator of cystic fibrosis membrane conductance regulator (CFTR) is provided. The compound represented by the formula 1, which is a modulator of CFTR activity, is 2-chloro-1,3-dimethyl-2-imidazolium tetrafluoroborate, HBTU, HCTU, 2-chloro-4,6-dimethoxy. A method for coupling a dihydroquinolinecarboxylic acid derivative with an aniline derivative in the presence of a coupling agent selected from 1,3,5-triazine, HATU, HOBT / EDC and T3P®. [Selection figure] None |