| abstract |
An object of the present invention is to provide a pre-tablet material that does not break internally when a polymer-containing pre-tablet material is compressed in a non-lubricated die blended with a lubricant. A pre-tabletting material comprising at least one therapeutic agent and at least 30% by weight of at least one pharmaceutically acceptable polymer, wherein the material is compressed in a die at a compression pressure of at least 10 kN / cm 2. The tablet is formed and the inner surface of the die is lubricated with at least one lubricant, the material does not contain any lubricant, or the total amount of lubricant or lubricants in the material Is less than 0.2% by weight of the material, and the material is (1) denatured or inactivated when compressed at a pressure equal to or greater than 10 KN / cm2, and (2) equal to 10 KN / cm2 or A pre-tabletting material that does not contain a therapeutic agent that is delayed in its dissolution when compressed at pressures above it, or (3) is affected by at least one lubricant. [Selection figure] None |