| abstract |
Specific transporter-load conjugates for transporting a target substance (a cargo molecule) to leukocytes for use in the treatment, prevention, attenuation and / or recovery of diseases and / or disorders involving leukocytes The use of gate molecules. A transporter-loading conjugate molecule comprises a) a (poly) peptide comprising, as component (A), an amino acid sequence represented by HIV TAT residues 49 to 57 (SEQ ID NO: 2) or a variant thereof. B) as component (B), a cargo molecule (pharmaceutically active), and c) one or more optional components, wherein the variant of the amino acid sequence represented by SEQ ID NO: 2 is i) sequence A (poly) peptide comprising at least one amino acid sequence according to number 235 or a reverse sequence thereof, and ii) a (poly) peptide comprising at least one amino acid sequence according to any one of SEQ ID NOs: 2-116 or a reverse sequence thereof , Characterized in that it is selected from the group consisting of: [Selection figure] None |