abstract |
Disclosed are a compound having an excellent inhibitory effect on pim-1 kinase and useful for leukemia and prostate cancer, and an anticancer agent containing the compound as an active ingredient. A compound represented by formula (I) and an anticancer agent comprising the compound as an active ingredient. [R1 is H, OH, C1-6 alkoxy group, etc .; R2 and R3 are H, halogen atom, C1-6 alkyl group, etc .; R4 is H, C1-6 alkyl group, C1-6 alkylsulfonyl group, etc .; H or a substituent; ---- is a single bond or double bond; R 6 and R 7 are H, C 1-6 alkyl group, etc .; R 8 is H, C 1-6 alkyl group, etc .; A is āOā, āSā Or -CH2-; D is -C = or -N =; X is a methylene group, -O- or -CO-; Q is -N = or -C (R8) =; Y is a heterocyclic group or amino [Base] [selection figure] None |