| abstract |
[Problem] To provide a method for producing a precursor for use in the production of pharmaceutical alformoterol. An optically active N-benzyl-4-methoxyphenylpropylamino compound and 4-benzyloxy-3-nitro-haloacetophenone are reacted to form a precursor ketone, and this carbonyl group is reduced to produce an optically active 3 -A method for producing a nitrophenylhydroxylamino compound, and further reducing the nitro group to produce an (R, R) diasteromer or a salt thereof, which is a precursor of the production of alformoterol represented by the formula (VI). (R1 and R2 are benzyl groups, etc.) [Selection] None |