| abstract |
The present invention provides a means for immunizing newborn humans and newborn animals against foreign antigens and antigens associated with human and animal diseases, respectively. [Solution] The present invention relates to a method of using a virus in the manufacture of a medicament for immunizing or treating a newborn or prenatal animal, including a human, wherein the virus infects cells of the newborn or prenatal animal, including a human. It relates to a method of use as described above, characterized in that the neonatal or prenatal animal, including humans, does not have the ability to replicate to infectious progeny virus. The virus is preferably a mutant vaccinia virus Ankara. In particular, the present invention relates to vaccination of newborns against infection by viruses belonging to the same virus group as the virus used for vaccination. The present invention also relates to neonatal vaccination against an antigen selected from a foreign antigen and a tumor antigen different from the antigens related to the virus. Furthermore, the present invention increases the level of factors that activate dendritic cells or their progenitor cells, and / or increases the number of dendritic cells or their progenitor cells, and / or interferon (IFN) Alternatively, it relates to a method of using a virus as defined above for the purpose of increasing IL-12 production and / or cell content. [Selection figure] None |